Successful Mapping of the Genetic Blueprint of 13 Strains of Lyme Disease

Successful Mapping of the Genetic Blueprint of 13 Strains of Lyme Disease

Dr. Luft at Stony Brook University Medical Center is once again on the forefront of exciting and meaningful new discoveries regarding Lyme disease that may actually change the face of our hopeless battlefield between modern medicine and the spirochete Borellia burgdorferi.

In addition to Dr. Luft, co-authors of “Whole Genome Sequences of Thirteen Isolates of Borrelia burgdorferi” include: Dr. Steven E. Schutzer, Department of Medicine, University of Medicine and Dentistry of New Jersey; Dr. Claire M. Fraser-Liggett and Dr. Emmanuel F. Mongodin of the Institute for Genome Sciences, University of Maryland; Dr. Sherwood R. Casjens, Department of Pathology, University of Utah Medical School; Dr. Wei-Gang Qiu, Department of Biological Sciences, Hunter College of the City University of New York, and Dr. John J. Dunn, Biology Department, Brookhaven National Laboratory.

According to “Newswise”, the finding is crucial to advancing research on Lyme disease, the most frequent tick-borne infection in North America and Europe, and may lead to better diagnostics and a vaccine. Dr. Luft presented the research results at an October 11 meeting in Washington, D.C., at the Institute of Medicine, an arm of the National Academy of Sciences. Read more about the incredible importance of this achievement – the study is reported in the early online edition of the Journal of Bacteriology at http://jb.asm.org, and Long Island’s “Newsday” (picture compliments of Newsday photos)

The first complete genome sequence of one strain of B. burgdorferi more than 10 years ago has helped researchers understand the pathogenesis of the disease. However, this understanding was limited with only a single genome sequence on one strain completed. By determining all genome sequences of B. burgdorferi, the researchers are providing a foundation for novel detection of Lyme disease, diagnostic approaches and prevention strategies. The timing is critical, as disease occurrence has become widespread over the past decade throughout the United States and part of Europe.

“By characterizing every gene in the Lyme disease agents family, we have a blueprint of every possible characteristic of the organism,” says Dr. Luft, senior author on the study. “This is the building block to developing more accurate and effective diagnostic tests, therapeutic agents and vaccines.

“We are depositing the millions of nucleotides that we have sequenced in the public database so that this valuable information will help to further enhance our research and that of other Lyme disease investigators.”

Dr. Luft and colleagues point out in the study that improved diagnostics are needed because the best clinical sign of Lyme disease, the erythema migrans skin rash, does not always occur in patients. In addition, diagnostic assays and vaccines developed before their blueprint of the entire genome of B. burdorferi have had less than satisfactory results.

“A driving force for doing this project was the observation that certain forms of the bacteria can be more invasive than others,” adds Dr. Steven E. Schutzer, lead author, and Professor of Medicine, University of Medicine and Dentistry of New Jersey. “We wanted to find out why and how to identify this property.”

Originally posted October 12, 2010

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