Reservoir Targeted Vaccine for Lyme Borreliosis Induces a Year Long, Neutralizing Antibody Response to OspA in White-footed Mice.

Authors: Meirelles Richer L, Aroso M, Contente-Cuomo T, Ivanova L, Gomes-Solecki M Abstract Lyme disease is caused by the spirochete Borrelia burgdorferi. The enzootic cycle of this pathogen requires that Ixodes spp. acquire B. burgdorferi from infected wildlife reservoirs and transmit it to other uninfected wildlife. At present, there are no effective measures to control B. burgdorferi; there is no human vaccine available, and existing vector control measures are generally not acceptable to the public. However, if B. burgdorferi could be eliminated from its reservoir hosts or from the ticks that feed on them, the enzootic cycle would be broken, and the incidence of Lyme disease would decrease. We developed a reservoir targeted bait vaccine (RTV) based on the immunogenic outer surf…

Authors: Meirelles

Richer L, Aroso M, Contente-Cuomo T, Ivanova L, Gomes-Solecki M

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