Anyone with Lyme disease understands that there is neurological involvement with every symptom. Inflamed nerves cause pain whether it is felt from nerves in joints or nerves in the head, it is the inflammation that registers as pain.So the latest research on neuro-inflammation is especially helpful for developing therapies to cope with the intense neurological pain suffered by the victims of Lyme disease.
Lyme disease in its early stages can cause mild to severe flu-like symptoms, and except in extreme cases neurological symptoms develop later if the disease is misdiagnosed or not treated strongly enough initially.
In a study recently published in Nature Immunology, a team led by Prof. Philippe Gros show that genetic inactivation of this protein pair blocks neuroinflammation and prevents the appearance of disease in animal models of multiple sclerosis (MS). The findings could pave the way for development of novel therapeutic approaches in inflammatory diseases such as MS. The study involved a close collaboration among scientists at the McGill Research Centre on Complex Traits, the Montreal Neurological Institute, and the McGill University and Génome Québec Innovation Centre.
The researchers have identified two proteins that work together to drive neuroinflammation in acute conditions such as microbial or autoimmune encephalitis, and in chronic conditions such as multiple sclerosis. Any therapeutic treatments developed would also benefit anyone suffering from nerve inflammation like Lyme disease, Fibromyalgia and CFS/ME.