New Lyme Test – Nano Technology

New Lyme Test - Nano Technology

Finally the Ceres Lyme test has come to market. This new test will benefit everyone. Not only does it reliably detect early Lyme disease, but it is able to detect chronic cases of Lyme disease as well.The target of the Nanotrap® LA Test measurement, Outer surface protein A (OspA), was identified as a valid biomarker for detecting Lyme disease based on the following findings from highly regarded scientific publications: OspA is a protein found only on the surface of Borrelia burgdorferi (Bb), and OspA antibodies are detectable in patients in early and late stage disease (Infect. Immun. 1995, 63:2228-2235) and in antibiotic resistant Lyme (Arthritis Rheum. 1999 42:1809-1812); Bb expresses high levels of OspA in the mammalian host in an inflammatory environment (Infect. Immun. 2003, 71,7; 4003-4010); OspA has inflammatory properties (stimulation of neutrophils, The Journal of Immunology, 1997, 4838); OspA and surface lipoproteins provide protective shielding against mammalian host innate immunity (Mol Microbiol. 2008; 69(1): 15–29); OspA has been found in Lyme patient urine, cerebrospinal fluid and synovial fluid.

George Mason University set up its own trial, in partnership with Ceres Nanosciences, Inc, and multiple infectious disease clinics and internal medicine practices to further develop this finding into a reliable diagnostic test.

Over 300 patients participated in the clinical trial. Urine samples were collected from every patient and both the current standard of care serological testing and the Nanotrap® LA Test were run for each patient sample and analyzed in conjunction with the physician’s report of symptoms and history with Lyme disease. This study has been published in a peer reviewed scientific journal, Journal of Translational Medicine: Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis.

The study demonstrates the following key findings: Bb antigen OspA is present in the urine of patients at early stage disease (sensitivity < 1.7 pg/mL); Patients who were asymptomatic following treatment were noted to revert from positive to negative; For patients under treatment for Lyme disease, the presence of antigen in the urine correlates strongly  with the presence of symptoms; Bb antigen is shed in the urine only in presence of active infection producing symptoms. 

This new test is available through labs for about $400 as of this writing.

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14 Responses to New Lyme Test – Nano Technology

  1. Jim says:

    This is fabulous! Like many others, I was given the ELYSA test numerous times over the years before it finally came back positive. That finally convinced the doctors to treat my suspicions seriously and I subsequently showed positive on several bands in a Western Blot test. My current LLMD is certain I have carried the infection for years, which explains many mysterious maladies I’ve dealt with. While this development is late to help me (I’m finally under serious treatment), I hope that thousands of unknown Lyme sufferers will benefit. If the true prevalence of Lyme comes to light, maybe more primary care givers might finally become better educated on diagnosing and treating this epidemic, not to mention the CDC. Thanks!

    Jim

    • Jenna Seaver says:

      I hope you are healing well now that you are getting proper treatment. As you know, our health crisis is exasperated by the controversy within the medical community. I truly think that is beginning to change with new scrutiny and research from John Hopkins, Sanford and other top university research. Hopefully a cure will be found soon –

  2. Anne says:

    Jenna – Great Stuff! Is it only available in USA? Which are the labs we can contact? Thanks for great articles!

  3. Cindy says:

    Promising news. Is this test being offered across the country? Is any portion of the test covered by insruance?

  4. Kristin says:

    My LLMD in MI is doing this test and I had it done in March. I came back as negative. I had 7 mths of abx treatment so either the Lyme is now gone…OR I never had it in the first place despite positive Igenex results. My LLMD is now testing all her patients and 85% are coming back negative! She is now treating this group for CIRS/Immune dysfunction if we meet the criteria. She said this has impacted her practice and treatment methods immensely…definitely evolving with much needed new tests/technology.

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