New Biofilm Busting Protocols For Chronic Lyme Disease

New Biofilm Busting Protocols For Chronic Lyme Disease

This picture (courtesy of “Nature Review”) is worth a thousand words if you are trying to describe the life cycle of a biofilm.*

What does a biofilm have to do with Lyme disease?

Towards the end of the documentary “Under Our Skin” there is a brief interview of Dr. Alan MacDonald who is given credit for discovering the role of biofilms in protecting spirochetes from antibiotics and/or organic bactericides, although Dr. MacDonald publicly credits Dr. Evi Sapi.  This discovery has stimulated a wave of research regarding biofilms and their role in chronic Lyme disease with some exciting progress. At the time of the movie’s production this was cutting edge research. See

*NOTE: Today (October 2015) the most promising treatment for Lyme disease rests with “Curza” a new drug currently waiting for FDA approval which targets both the biofilm and the bacteria – see

As research papers trickled out, Lyme-literate doctors and doctors who are willing to try new methods to alleviate the pain and suffering of their chronic Lyme patients were given more tools to fight this insidious disease. A number of new protocols emerged with exciting results.

In order for you to better understand some of the background of these methods, it is necessary to go back in time ten to twenty years. In the early years of the Lyme Epidemic…

It has been known by “alternative care” doctors for many years that “chelation” brought about herxheimer effects (indicating toxic spirochete die-off) and improvement in symptoms in Lyme patients, but it was not clearly understood why. Some believed that it was due to mercury poisoning in addition to Lyme and co-infections.

We now have evidence that the spirochete, described by many as the most intelligent bacteria ever discovered, cleverly snatch bits and pieces of organic material to build their colonies (the biofilm) in order to hide from our immune system. The biofilm is made up of primarily calcium, magnesium, mercury, lead, copper and other metals and trace elements which are weakened by chelation allowing the immune system to identify the invaders and kill the bacteria.

Additionally, it is well known in the medical world that “proteolitic” enzymes are effective at dissolving biofilms. With extensive research, certain enzymes prove more lethal to Lyme biofilm than others (see, and

Since the time I wrote those posts, much more information has been discovered and products developed. Concurrently, as I mentioned before, there are a group of pioneering doctors who are testing different protocols based on what seems to work for their patients.

Of course nothing works identically on every Lyme patient, so I will attempt to provide what makes sense to me and give you links to other sites that have varying protocols.

The quality, composition and strength of the enzymes is of the greatest importance, and I have provided the full protocol with resources where to find the appropriate products. Don’t expect this protocol to work with just any enzyme product (you will quickly learn that every enzyme manufacturer will tell you that their product is the best.)

I am not a licensed medical practitioner, but I am happy to share with you the protocol that I use based on the research I have done. If you are interested in this protocol, I urge you to go to your Lyme-literate doctor and make sure he or she approves. The enzyme I use is a blood thinner which could be problematic for some people so don’t go into this lightly. You can find all of the information on my biofilm busting protocol at

Also, be prepared for a herxheimer reaction if you have had chronic Lyme disease for a long time. This protocol is very uncomfortable but as we all say, “You have to get worse to get better!”

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12 Responses to New Biofilm Busting Protocols For Chronic Lyme Disease

  1. Kimberly says:

    Hi, I visited your very helpful site a while ago and cam back to find the biofilm buster protocol you had posted earlier. Unfortunately the page is not working now. Hopefully you can make it available again. Thanks so much for sharing your experience and education on the topic …
    – k

    • Jenna Smith says:

      Have had difficulties since my hosting account was hacked and deleted (including backups!) I have been working the best I can and have had generous donations for help from Elance to put my blogs back together…I appreciate your patience! I thought I had those working first. Meanwhile read and within a week the other posts should be repaired.

  2. Merry says:

    Thank you so much for your information. I look forward to reading your links when they are working again. My husband has been disabled by chronic Lyme for 12 years and I would love to learn more about this protocol.

  3. Posy bass says:

    Hi Jenna, I tried your link to your biofilm treatment protocol and it doesn’t work anymore. Can you help me?
    Thanks, Posy

  4. Jim Keating says:

    I have seen recent information that RA may be caused by biofilms that can be destroyed by certain antibodies and a specific blood pressure medication . It states Vitime D excess causes the VDR to stop
    working . Do you think this is possible ? It sounds like chelation would be more effective.

  5. Christopher Pentell says:

    Attention all Lymies ——– Biological Factoid —- The Bb spirochete can not , will not survive under a constant barrage of hyperbaric oxygen treatment ( about a month ) I have been treating Lyme quite successfully for years now . Why d on’t your doctors recommend this holistic protocol ? Maybe its the $$$ . My fee? Whatever they can afford (chgo. area)

    • Jenna Smith says:

      Remember Christopher that not all people suffering from chronic Borrelia respond to treatments in the same way depending on a variety of issues, but for those who can’t find a successful treatment HBO is definitely something to be explored by a reputable company.


  6. tay diggens says:

    I wanted to invite people to look at this other great article I stumbled across about biofilm. Here it is here

  7. Vlynx says:

    Where did the idea that Alan MacDonald has Alzheimer’s come from? He has also been reported to be dead! I think he would disagree. He is alive and well and actively researching borelliosis, biofilms and Alzheimer’s disease.

    • Jenna Seaver says:

      I apologize – if you read my blog posts about Dr. MacDonald you will see I corrected my error and try to pass on his amazing research every chance I get. I am a true fan of his.


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