Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model

Conclusions Our data indicate that topical treatment with a formulation containing azithromycin is a promising approach to prevent Lyme borreliosis shortly after a tick bite. (Source: Journal of Antimicrobial Chemotherapy)

 

Objectives

Systemic antibiotic treatment of Lyme borreliosis is effective during the early stages of the infection, while chronic manifestations of the disease may remain refractory and difficult to treat. This study was carried out in order to evaluate the potential of topically applied azithromycin to eliminate the spirochaetal organisms in the skin of the freshly bitten host and thereby prevent Lyme borreliosis.

Methods

Laboratory mice were challenged with

Borrelia burgdorferi sensu stricto

Results

Concentrations of azithromycin in murine skin were >3800-fold higher than the published minimal inhibitory concentration for

B. burgdorferi

Conclusions

Our data indicate that topical treatment with a formulation containing azithromycin is a promising approach to prevent Lyme borreliosis shortly after a tick bite.

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