Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells

AbstractInteraction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia‐stimulated DCs and the ability of Borrelia‐exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia‐exposed DCs to induce both proliferation and IL‐2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF‐α and IL‐6) and Th2 (IL‐10) cytokines by DCs. Our data reveal a complex inhibito…

AbstractInteraction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different

levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia‐stimulated DCs and the ability of Borrelia‐exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia‐exposed DCs to induce both proliferation and IL‐2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have

shown an inhibitory effect of tick saliva on the production of both Th1 (TNF‐α and IL‐6) and Th2 (IL‐10) cytokines by DCs. Our data reveal a complex inhibito…

Source:

(Visited 8 times, 1 visits today)
Subscribe to Jenna's Lyme Blog
Yes, I want to subscribe. I understand I will only receive one email each month when there are new posts.
This entry was posted in Lyme Disease News. Bookmark the permalink.

Leave a Reply

Your email address will not be published. Required fields are marked *