Desloratadine, a Common Antihistamine May Treat Lyme Disease

Desloratadine, a Common Antihistamine May Treat Lyme Disease

It is always good news when researchers find something that discourages the stealthy and seemingly incurable Lyme disease.

A recent medical report was just released on February 10, 2015 by  Jayakumar Rajadas, PhD, director of the Biomaterials and Advanced Drug Delivery Lab at Stanford University School of Medicine along with a team of researchers (see report at link in Sources at Dove Press).

Rajadas and colleagues combined computer-simulated protein structure prediction with molecular docking to target the B. burgdorferi metal transporter A (BmtA). The researchers then viewed libraries of FDA-approved compounds that could potentially bind to the predicted BmtA structure.

Evidently, Borrelia needs magnese to function in the human body. As the growth cycle of the bacteria was studied by Stanford University School of Medicine, it was discovered that Desloratadine (also known as Clarinex, NeoClarityn, Claramax, Clarinex, Larinex, Aerius, Dazit, Azomyr and others)

“Our results bring us closer to the possibility of discovering the first targeted therapy to treat Lyme disease,” Rajadas said in a press release. “It’s exciting to see firsthand that our insights into the metabolic activity of this elusive bacteria may give us the ability to actually kill it.”

Antihistamines such as desloratadine, the major active metabolite of loratadine, and 3-hydroxydesloratadine, as well as yohimbine and tadalafil, demonstrated tight binding to the transporter.

Treatment samples of desloratadine, commonly used to combat allergy symptoms, caused a reduction in bacterial pellet size and mass. However, Rajadas and colleagues indicated more research is needed to see if desloratadine can eradicate B. burgdorferi.

“Whether Borrelia has the ability to develop resistance to desloratadine-like compounds is an important question and should be addressed in future studies,” the researchers wrote. – by Ryan McDonald

Disclosure: Wagh reports being listed on a patent for Inhibitors of Borrelia Metal Transporter for Treatment of Lyme Disease assigned to Stanford University. See the full study for a list of all other authors’ relevant financial disclosures.

 SOURCE:

http://www.dovepress.com/borreliacidal-activity-of-borrelia-metal-transporter-a-bmta-binding-sm-peer-reviewed-article-DDDT

http://en.wikipedia.org/wiki/Desloratadine

http://www.healio.com/allergy-immunology/drug-food-insect/news/online/%7B972c5c71-7070-41bd-be14-73ab5e232526%7D/desloratadine-may-kill-lyme-disease-causing-bacteria

(Visited 175 times, 1 visits today)
Subscribe to Jenna's Lyme Blog
Yes, I want to subscribe. I understand I will only receive one email each month when there are new posts.
This entry was posted in Alternative Treatment Protocols, Lyme Disease Treatment, Research and Development and tagged , , , . Bookmark the permalink.

5 Responses to Desloratadine, a Common Antihistamine May Treat Lyme Disease

  1. Theresa Lee says:

    The word is MANGANESE, not “magnese” as you state. Also, do not confuse that with magnesium. The proper element in play here is MANGANESE. Check the actual scientific report to confirm.

  2. Kelly Clover says:

    My sister pointed out something I was otherwise unaware of until I checked it out. There are multiple Youtube healing frequency tapes on the internet. These frequency healing tapes deal with a huge number of different health conditions. Some of these tapes seem to be quite powerful. You will feel something after playing them for awhile. I believe that some chronic Lyme disease patients will find some of these tapes to be powerful and possessing a tangible benefit. For example there are multiple tapes for candida, a common co-infection with borrelia. Some of these tapes could help to heal certain parts of the body adversely affected by chronic Lyme. There are tapes that deal with digestive problems, heart problems, eyesight problems, ear infections, kidney disease and whathaveyou. Some of these tapes are 60 minutes in length. Others are shorter. If you type in “Youtube Intestinal Healing Karmic” or “Youtube Candida Isochronic” or some similar phrase you can find many of these powerful healing frequency tapes.

  3. Carol says:

    I’ve read 400mg might be the dose.
    I used to live on antihystamine as a child. 4 a day.
    I tried them for a day or two. Even the non drowsy have a sleeping effect.
    They are closely related to antidepressant and sleeping pills there’s even a link to antibiotics.
    These produce qunolinic acid a neurotoxin and so do infections like
    Lyme. There’s a feed back mechanism. 5ht Saint John’s wort are also linked. 5ht crosses the blood brain barria.
    Serlenium is also linked.
    The body closes the iron channel to kill infections but it can close the manganese channel.
    We need to look at elements above manganese and below.
    As in the appearance of too much Salt is as a result of not enough magnesium. Too much heavy metal is to do with the higher elements missing. They come out of solution.
    The experts didn’t seem to understand basic chemistry.
    I have problems with too much magnesium I am unable to absorb it.
    If I go to a place where there is too much in the water.
    There’s a link to sulphur not being
    Metabilzed that links to sugar.
    Diabetes seems to be linked to manganese and vitiam D defficency as well as gut bacteria:

Leave a Reply

Your email address will not be published. Required fields are marked *