Antibody profiling Borrelia burgdorferi infection in horses.

Authors: Burbelo PD, Bren KE, Ching KH, Coleman A, Yang X, Kariu T, Iadarola MJ, Pal U Infection with Borrelia burgdorferi (Bb) is common in horses and ponies from the New England and Mid-Atlantic regions of the United States. Here, we evaluated Luciferase Immunoprecipitation Systems (LIPS) for profiling antibody responses against three different antigenic targets for the diagnosis of equine Bb infection. LIPS testing of horse serum samples suspected of Lyme infection revealed that approximately 75% of the horse samples (114/159) were seropositive against the synthetic VOVO antigen comprising repeated immunodominant C6 epitopes, as well as OspC immunodominant epitopes. Comparison of VOVO with immunofluorescence assay (IFA) showed that 51% of the samples were co-positive in both assays,…

Authors: Burbelo PD, Bren KE, Ching KH, Coleman A, Yang X, Kariu T, Iadarola MJ, Pal U

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