Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato

AbstractLyme disease (LD) is the most common tick‐borne disease in the Northern hemisphere. It is caused by Borrelia burgdorferi sensu lato, in particular B. burgdorferi sensu stricto, B. garinii and B. afzelii. However, other genospecies have been implicated as causative factors of LD as well. B. burgdorferi exhibits numerous immunogenic lipoproteins, but due to strong heterogeneity, the use of these proteins for serodiagnosis and vaccination is hampered. We and others have identified acylated cholesteryl galactosides (ACGal) as a novel glycolipid present in B. burgdorferi sensu stricto, B. afzelii and B. garinii. ACGal is a strong antigen and the majority of patients display anti‐ACGal antibodies in chronic stages of LD. However, it is unknown whether ACGal is present in other presum…

AbstractLyme disease (LD) is the most common tick‐borne disease in the Northern hemisphere. It is caused by Borrelia burgdorferi sensu lato, in particular B. burgdorferi sensu stricto, B. garinii and B. afzelii. However, other genospecies have been

implicated as causative factors of LD as well. B. burgdorferi exhibits numerous immunogenic lipoproteins, but due to strong heterogeneity, the use of these proteins for serodiagnosis and vaccination is hampered. We and others have identified acylated cholesteryl galactosides (ACGal) as a novel glycolipid present in B. burgdorferi sensu stricto, B. afzelii and B. garinii. ACGal is a strong antigen and the majority of patients display anti‐ACGal antibodies in chronic stages of LD. However, it is unknown

whether ACGal is present in other presum…

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