It is being called “Rewriting the Code of Life” according to a recent article in New Yorker Magazine. The idea is to manipulate DNA code in individuals to make us immune to certain diseases like cancer and yes, even Lyme disease. Continue reading
Have you heard about LDN (Low Dose Naltrexone) for chronic Lyme disease? I am excited to say that I have been taking it successfully for chronic pain although it took awhile to kick in. Continue reading
We made it through another year! It has been awhile since I posted about my own journey, and I thought this was a good time to share my personal progress, and encourage the many people who seem to be stuck in chronic illness. Continue reading
Cats Claw is a vine commonly known as Una de Gato and is used traditionally in Peruvian medicine for the treatment of a wide range of health problems, particularly digestive complaints and arthritis and to treat wounds, stomach problems, cancer, and more. Continue reading
Fantastic news regarding Lyme prevention this week – the Medical University of Vienna along with partners have developed a antibiotic gel (azithromycin) which combats Lyme disease if used within 72 hours of being bitten. Continue reading
Lyme carditis is a stealthy and deadly form of Lyme disease that gets little to no attention. Many people with heart disease have no idea that their heart problems are caused by Borrelia – or Lyme disease.
A new book on chronic Lyme has hit the streets and this one is worth reading. Written by Allie Cashel, the story chronicles her journey navigating the pain and suffering of chronic Lyme and ultimately the positive transformation in her life. Continue reading
We know that Lyme disease is a stealth pathogen, and we know that it can infect the heart and cause heart carditis. But for some this occurs unknowingly and can cause death and/or heart disease. Continue reading
Today, Lyme disease vaccines currently exist for dogs, but none have been approved for humans in nearly 15 years — and in that time the disease has grown into a world-wide epidemic. Continue reading
For those who missed the news, Massachusetts lawmakers voted this year to require insurers to cover long-term antibiotic treatment of Lyme disease in spite of a governor’s veto and doctor objection. Continue reading
Tom Balsamides, an award-winning filmmaker, witnessed the debilitating effects of Lyme disease on his wife Tamara, who struggled for 10 years without a diagnosis and another five until she regained her health and her life. See trailer below… Continue reading
The 1st annual conference “Lyme Disease in the Era of Precision Medicine” was hosted in October 2016 by Mount Sinai’s Institute for Next Generation Healthcare. This unique event sponsored by the Steven & Alexandra Cohen Foundation: Lyme Disease Initiative, focused on opportunities to apply emerging paradigms of precision medicine and network biology to advance understanding and treatment of Lyme disease.
Canadians with Lyme disease, like Australians, have been ridiculed for decades over the idea that they could contract Lyme disease in a place that doctors insisted it did not exist. Continue reading
FOR IMMEDIATE RELEASE
Newswise — Johns Hopkins University received a $10 million grant from the Steven and Alexandra Cohen Foundation to explore Lyme disease and develop potential new therapies to address the illness. Johns Hopkins is the only institution in the nation to receive multiple Lyme disease grants from the foundation.
The grant will be divided among three Johns Hopkins research teams led by John Aucott, M.D.; Ying Zhang, M.D., Ph.D.; and Brian Schwartz, M.D.
John Aucott, M.D.
John Aucott, M.D., assistant professor of medicine, and colleague Mark Soloski, Ph.D., professor of medicine, both of the Johns Hopkins University School of Medicine, received a five-year grant for $6 million to support the continuation of the Johns Hopkins Lyme Disease Research Center’s Study of Lyme Disease Immunology and Clinical Events, a longitudinal effort that identifies patients at the onset of Lyme disease, initiates standard treatment and follows them over a one-year period. The aim is to characterize those patients that develop post-treatment Lyme disease syndrome and analyze the immunological pathways triggered as the disease progresses in those patients.
“This grant allows us to expand our research and gain a better understanding of the disease,” Aucott says. “It also allows for greater diversity among participants so we can get more substantive information that can inform future developments in the field of Lyme research and discovery.”
Aucott and Soloski’s work will involve detailed clinical, immunological and molecular profiling, and will be done in collaboration with Joel Dudley, Ph.D., assistant professor of genetics and genomic sciences and director of biomedical informatics at the Icahn School of Medicine at Mount Sinai, in New York City. Dudley will support Aucott and Soloski by developing high-level computer modeling that will aid in the analysis of the large data sets.
With support from the grant, Aucott, director of the Johns Hopkins Lyme Disease Research Center, plans to open a new research site each year of the grant. For year one, he has already begun expanding the Green Spring Station clinical research site in Lutherville, Maryland, nearly doubling the number of exam rooms. Aucott also plans to build a Lyme research clinic at Johns Hopkins Bayview Medical Center. For the second year, he is looking to set up a site in Howard County, Maryland. For year three, he hopes to expand into Pennsylvania. His plans for years four and five will explore sites throughout the East Coast.
“As Lyme cases continue to increase in the U.S., there is an increasing need to understand the disease and its outcomes,” says Aucott. “We have no way of predicting who will recover and who won’t. This grant will allow us to explore why post-treatment Lyme disease syndrome exists, the mechanisms behind the disease and the pathways through which it causes symptoms so that one day, we can use that information to develop ways to prevent the disease or develop more effective drugs. Currently, we don’t have a full understanding of the disease or the most effective ways to treat those it impacts.”
Ying Zhang, M.D., Ph.D.
Ying Zhang, M.D., Ph.D., professor of molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health, received $2.5 million from the foundation for a five-year grant that will allow him and his team to test potential new ways to treat Lyme disease. The grant will support Zhang’s efforts to develop optimal drug combinations to more effectively combat post-treatment Lyme disease syndrome, focusing on developing effective oral drug combination regimens. First, Zhang and his team will develop an oral version of a triple-drug combination that currently is only available through IV. The oral drug combinations will then be tested in vitro (test tube) for effectiveness against Borrelia persisters using novel methodologies recently developed by his group. Next, the drug combinations will be tested in a mouse model of persistent Lyme disease to confirm efficacy, followed by validation in a monkey model, to be performed by his collaborator Monica Embers, Ph.D., from Tulane University.
“This grant is very important for us because it provides stability to the Lyme research program here at Johns Hopkins,” Zhang says. “It will allow us to advance potential new and more effective therapies for this complex and intriguing disease. There is currently no therapy available that effectively treats post-treatment Lyme disease syndrome. “We may be able to fast-track the development of new and better ways to treat the disease.”
Brian Schwartz, M.D.
Brian Schwartz, M.D., professor in the Department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health, received more than $1 million from the foundation to conduct a three-year, two-phase investigation of Lyme disease in Pennsylvania, one of the hardest-hit regions for the disease.
In phase I, Schwartz and colleagues will conduct a large-scale, population-based study of the epidemiology of Lyme disease using data from electronic health records from the Geisinger Clinic. These data are available for over 500,000 patients from 2001 to present. Schwartz and colleagues will link that information to community data on land use and land cover — for example, agricultural land, forested land and low-density suburban development. In addition, Schwartz will evaluate populations vulnerable to Lyme disease, delayed diagnosis and treatment by looking at these features by age, sex, race/ethnicity, family socioeconomic status, community socioeconomic status, and a variety of other community and environmental variables.
For phase II, a questionnaire-based study will be performed to assess vulnerabilities within the population. This will include aspects of individual, occupational and community risks, as well as an assessment of people’s knowledge, attitudes and practices regarding Lyme disease diagnosis, treatment and long-term prognosis. Investigators will also analyze who is getting Lyme disease and why, how long it takes until diagnosis, and appropriate treatment. This research will allow for the evaluation of Lyme disease risk, and assess diagnosis and treatment patterns, with a goal of identifying new management strategies to address Lyme disease.
Discovered more than four decades ago, Lyme disease has now spread rapidly throughout the East Coast and Midwest. It is estimated to afflict more than 300,000 people per year, becoming the sixth most common reportable infectious disease in the U.S. However, little is understood about the complex pathogenesis of the disease, which costs the U.S. economy up to $1.3 billion per year in treatment costs alone.
Copied from Newswise press release
Spaulding Hospital, ranked 5th in the country among rehabilitation hospitals by US News & World Report has opened a special center for chronic Lyme disease in Boston Massachusetts, to deal with the Lyme epidemic in the Boston area. Continue reading
by Daniel Cameron MD MPH Continue reading
Talk to someone suffering with chronic Lyme disease, and chances are, they have been prescribed some form of medication for pain. More often than not, the medication is opiate based (or synthetic) and marks yet another threshold of humiliation for the chronic Lyme sufferer. Continue reading
Once again Dr. Alan MacDonald impresses the medical community with his research into Borrelia and the devastating effects on the brain. The free video presentation on Vimeo follow a lecture presentation by MacDonald in London, May, 2016. Continue reading
People’s immune system react very differently to Lyme disease based on recent research published by Radboud University Medical Center, the University Medical Center Groningen (UMCG), the Broad Institute of MIT and Harvard recently (Oct 2016) in Cell Host & Microbe.
It is terrible to have chronic Lyme disease in the US, or anywhere in the world, but it is disastrous if you live in Australia. The dilemma: authorities are adamant that there is no Lyme disease in Australia, and claim that any positive blood test is the result of a false positive. However, symptomatic evidence suggest a vast epidemic that baffles experts and puts the sufferers in harms way. Continue reading
Although the study came out last December (2015), the CDC recently made waves by officially supporting the results of the study, conducted by Dr. Wormser and 10 of his closest anti-chronic Lyme cronies. Continue reading
Anyone with Lyme disease understands that there is neurological involvement with every symptom. Inflamed nerves cause pain whether it is felt from nerves in joints or nerves in the head, it is the inflammation that registers as pain. Continue reading
Subpoenas have been issued before the high court in Paris, targeting five companies that market the Lyme test, “Elisa” – the only test permitted initially in France to detect Lyme disease. Continue reading
Dr. Daniel Cameron has recently posted a great article on the possible complications with eye sight on his excellent Lyme blog. Continue reading
STAT News has recently released new information on Lyme disease from an unlikely source – the garage belonging to the late Dr. Willy Burgdorfer. The scientist who discovered Lyme disease back in 1978, Dr. Burgdorfer passed away in 2014 leaving cartons of notes and research after almost a half century of stellar research on tick-born diseases. Continue reading